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In the spotlight
What does letrozole do?
Aromatase inhibitors are drugs that inhibit the enzyme aromatase. They are used to treating breast cancer in postmenopausal women and for the treatment of gynecomastia. Letrozole is a selective, reversible, non-steroidal aromatase inhibitor. The enzyme catalyzes the conversion of androgens to estrogens, including testosterone to estradiol. Come find out more about it. How letrozole works Letrozole works in three stages. In women, before menopause, aromatization occurs primarily in the ovaries. During menopause, the amount of estrogen produced there decreases from 25 to 100 mcg (depending on the phase of the cycle) to 5 to 10 mcg per day. Estrogen is also formed from the androgen dehydroepiandrosterone, which is formed in the adrenal cortex and in the fatty tissue, especially after...
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